High-throughput fetal fraction amplification increases analytical performance of noninvasive prenatal screening.

Noah C WelkerAlbert K LeeRachel A S KjolbyHelen Y WanMark R TheilmannDiana JeonJames D GoldbergKevin R HaasDale MuzzeyClement S Chu

Published in: Genetics in medicine : official journal of the American College of Medical Genetics (2020)

FFA transforms low-FF samples into high-FF samples. By combining FFA with WGS-based NIPS, a single round of NIPS can provide nearly all women with confident results about the broad range of potential fetal chromosomal abnormalities across the genome.

Keyphrases

high throughput
pregnant women
nucleic acid
single cell
genome wide
human health
gene expression
risk assessment
liquid chromatography