Identification of active ingredients in Naomaitai capsules using high-resolution mass spectrometry unite molecular network analysis and prediction of their action mechanisms.
Shuang LiZhiyan LiuHaiping ZengJinyu FuMo SunChun BaoChenning ZhangPublished in: Rapid communications in mass spectrometry : RCM (2024)
In conclusion, this study has revealed that NMC acts on multiple targets in the body through various active components, exerting synergistic effects in the treatment of CI. Its mechanism of action may involve inhibiting neuronal apoptosis, oxidative stress and inflammatory responses as well as reducing cerebral vascular permeability and promoting cerebral vascular regeneration.
Keyphrases
- network analysis
- oxidative stress
- high resolution mass spectrometry
- subarachnoid hemorrhage
- liquid chromatography
- cerebral ischemia
- stem cells
- endoplasmic reticulum stress
- ultra high performance liquid chromatography
- gas chromatography
- dna damage
- cell death
- mass spectrometry
- single cell
- cell cycle arrest
- induced apoptosis
- tandem mass spectrometry
- combination therapy
- high resolution
- cell proliferation
- wound healing
- heat stress
- heat shock
- simultaneous determination