Novel eosinophilic gene expression networks associated with IgE in two distinct asthma populations.
Yamini V VirkudRachel S KellyDamien C Croteau-ChonkaJuan C CeledónAmber DahlinLydiana AvilaBenjamin A RabyScott T WeissJessica A Lasky-SuPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2018)
These results provide robust evidence that biologically meaningful gene expression profiles (relating to eosinophilic and regulatory T cell pathways in particular) associated with total IgE levels can be identified in individuals diagnosed with asthma during childhood. These profiles and their constituent genes may represent novel therapeutic targets.