The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma.
Carolina GiordanoLaura MarroneSimona RomanoGiuseppe Maria Della PepaCarlo Maria DonzelliMartina TufanoMario CapassoVito Alessandro LasorsaCristina QuintavalleGiulia GuerriMatia MartucciAnna Maria AuricchioMarco GessiEvis SalaAlessandro OliviMaria Fiammetta RomanoSimona GaudinoPublished in: Cancer research communications (2024)
Our research suggests that by combining imaging with analysis of monocyte/macrophage subsets in patients with GBM, we can enhance our understanding of the disease and assist in its treatment. We discovered a similarity in the macrophage composition between the TME and PB, and through association with imaging, we could interpret macrophages. In addition, we identified a predictive biomarker that drew more attention to immune suppression of patients with GBM.