Angiotensin-(1-7) mitigated angiotensin II-induced abdominal aortic aneurysms in apolipoprotein E-knockout mice.

Fei XueJianmin YangJing ChengWenhai SuiCheng ChengHongxuan LiMeng ZhangJie ZhangXing Li XuJing MaLin LuJinfeng XuMeng ZhangYun ZhangCheng Zhang

Published in: British journal of pharmacology (2020)

Ang-(1-7) treatment attenuated Ang II-induced AAA via inhibiting vascular inflammation, extracellular matrix degradation, and SMC apoptosis. Ang-(1-7) may provide a novel and promising approach to the prevention and treatment of AAA.

Keyphrases

angiotensin ii
angiotensin converting enzyme
extracellular matrix
vascular smooth muscle cells
oxidative stress
high glucose
diabetic rats
abdominal aortic
cell death
drug induced
endothelial cells