Autosomal dominant polycystic kidney disease in absence of renal cyst formation illustrates genetic interaction between WT1 and PKD1.

Johannes MünchKarin M KirschnerHendrik SchleeCornelia KrausRia SchönauerWenjun JinDiana Le DucHolger ScholzJan Halbritter

Published in: Journal of medical genetics (2020)

While the role of WT1 in glomerulopathies has been well established, this report by illustrating genetic interaction with PKD1 proposes WT1 as potential modifier in ADPKD.

Keyphrases

polycystic kidney disease
genome wide
copy number
gene expression
climate change