Placental-brain axis in females detected within broadly impacted metabolic gene networks protects against prenatal PCB exposure.

Kelly ChauKari NeierAnthony E ValenzuelaRebecca J SchmidtBlythe Durbin-JohnsonPamela J LeinIan KorfJanine M LaSalle

Published in: bioRxiv : the preprint server for biology (2024)

The female protective effect in prenatal PCB exposures appears to be mediated by dose-dependent sex differences in transcriptional modulation of metabolism in placenta.

Keyphrases

pregnant women
air pollution
gene expression
white matter
transcription factor
copy number
genome wide
resting state
genome wide identification
cerebral ischemia
heat shock
multiple sclerosis