The role of the gluteofemoral adipose tissue in cerebrovascular disease risk: evidence from a mendelian randomization and mediation analysis.

Evangelos Pavlos MyserlisMarios K GeorgakisLivia ParodiErnst MayerhoferJonathan RosandChirantan BanerjeeChristopher D Anderson

Published in: medRxiv : the preprint server for health sciences (2024)

Genetically proxied, BMI-independent higher GFAT volume is associated with reduced cerebrovascular disease risk. Although this is largely mediated by common vascular risk factor modification, targeting adipose-tissue specific pathways may provide additional cardiovascular benefit.

Keyphrases

adipose tissue
risk factors
insulin resistance
type diabetes
cancer therapy
metabolic syndrome