Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive Function: A Meta-analysis of Community-Based Cohorts.
Yuankai ZhangXue LiuKerri L WigginsNuzulul KurniansyahXiuqing GuoAmanda L RodrigueWei ZhaoLisa R YanekScott M RatliffAchilleas PitsillidesJuan Sebastian Aguirre PatiñoTamar SoferDan E ArkingThomas R AustinAlexa S BeiserJohn E BlangeroEric BoerwinkleJan BresslerJoanne E CurranLifang HouTimothy M HughesSharon L KardiaLenore LaunerDaniel LevyTom H MosleyIlya M NasrallahStephen S RichJerome I RotterSudha SeshadriWassim TarrafKevin A GonzálezVasan RamachandranKristine YaffePaul A NyquistBruce M PsatyCharles S DeCarliJennifer A SmithDavid C GlahnHector M GonzálezJoshua C BisMyriam FornageSusan R HeckbertAnnette L FitzpatrickChunyu LiuClaudia L SatizabalPublished in: Neurology (2023)
Higher mtDNA CN in blood is associated with better current and future general cognitive function in large and diverse communities across the US. Although MR analyses did not support a causal role, additional research is needed to assess causality. Circulating mtDNA CN could serve nevertheless as a biomarker of current and future cognitive function in the community.
Keyphrases
- mitochondrial dna
- copy number
- genome wide
- contrast enhanced
- current status
- lymph node metastasis
- dna methylation
- magnetic resonance imaging
- healthcare
- mental health
- white matter
- magnetic resonance
- computed tomography
- emergency department
- gene expression
- resting state
- brain injury
- blood brain barrier
- adverse drug
- diffusion weighted imaging