Highly Carbon-Selective Monofluoromethylation of β-Ketoesters with Fluoromethyl Iodide.

A highly carbon-selective monofluoromethylation of a broad range of β-ketoesters with fluoromethyl iodide under mild conditions is described. The uses of lithium tert-butoxide as the base and diglyme as the solvent made great contributions to the high C/O regioselectivity.