Combining phosphate binder therapy with vitamin K2 inhibits vascular calcification in an experimental animal model of kidney failure.
Aegida NeradovaGrzegorz WasilewskiSelene PriscoPeter LeendersMarjolein CaronTim WeltingBert van RietbergenRafael KramannJürgen FloegeMarc G VervloetLeon J SchurgersPublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2021)
In an animal model of kidney failure with vitamin K-deficiency, neither PB therapy nor vitamin K2 supplementation alone prevented VC. However, the combination of high vitamin K2 with PB treatment significantly attenuated VC.