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Disability improvement as a clinically relevant outcome in clinical trials of relapsing forms of multiple sclerosis.

Bruce Anthony Campbell CreeJeffrey A CohenAnthony T RederDavorka TomicDiego SilvaDaniela Piani MeierAnnik K LaflammeShannon RitterDavid LeppertLudwig Kappos
Published in: Multiple sclerosis (Houndmills, Basingstoke, England) (2021)
CDI and SDI are outcomes of interest for clinical trials and for long-term follow-up of participants with RMS. Monitoring CDI and SDI in addition to disability worsening may facilitate understanding of the therapeutic benefit of RMS treatments.
Keyphrases
  • multiple sclerosis
  • clinical trial
  • white matter
  • phase ii
  • open label
  • double blind
  • study protocol
  • systemic lupus erythematosus
  • adipose tissue
  • weight loss