Potential Use of DMSA-Containing Iron Oxide Nanoparticles as Magnetic Vehicles against the COVID-19 Disease.
Elisama S MartinsAriane EspindolaTatiane N BritosCamila ChagasEmerson BarbosaCarlos E CastroFernando L A FonsecaPaula S HaddadPublished in: ChemistrySelect (2021)
Iron oxide magnetic nanoparticles have been employed as potential vehicles for a large number of biomedical applications, such as drug delivery. This article describes the synthesis, characterization and in vitro cytotoxic in COVID-19 cells evaluation of DMSA superparamagnetic iron oxide magnetic nanoparticles. Magnetite (Fe3O4) nanoparticles were synthesized by co-precipitation of iron salts and coated with meso-2,3-dimercaptosuccinic acid (DMSA) molecule. Structural and morphological characterizations were performed by X-ray diffraction (XRD), Fourier transformed infrared (FT-IR), magnetic measurements (SQUID), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Our results demonstrate that the nanoparticles have a mean diameter of 12 nm in the solid-state and are superparamagnetic at room temperature. There is no toxicity of SPIONS-DMSA under the cells of patients with COVID-19. Taken together the results show that DMSA- Fe3O4 are good candidates as nanocarriers in the alternative treatment of studied cells.
Keyphrases
- iron oxide
- induced apoptosis
- magnetic nanoparticles
- drug delivery
- cell cycle arrest
- room temperature
- coronavirus disease
- electron microscopy
- sars cov
- solid state
- oxidative stress
- endoplasmic reticulum stress
- cell death
- signaling pathway
- magnetic resonance
- mass spectrometry
- magnetic resonance imaging
- photodynamic therapy
- risk assessment
- pi k akt
- climate change
- combination therapy