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Deep Eutectic Solvents Enhancing Drug Solubility and Its Delivery.

Anshu SharmaYea Rock ParkAman GargBong-Seop Lee
Published in: Journal of medicinal chemistry (2024)
Deep eutectic solvents (DES) are environmentally friendly solvents with the potential to dissolve bioactive compounds without affecting their characteristics. DES has special qualities that can be customized to meet the unique characteristics of a biomolecule/active pharmaceutical ingredient (API) in accordance with various therapeutic needs, providing a reliable approach in opening the door for the creation of cutting-edge drug formulations by resolving solubility issues in pharmaceutics. This study outlines newly developing approaches to solve the problem of inefficient API extraction due to poor solubility. These emerging strategies also have the capacity to alter the chemical and physical stability of API, which triggers drug's shelf life and their possible health benefits. It is anticipated that the highlighted methods and processes will be developed to capitalize on the DES potential to improve drug solubility and delivery in the pharmaceutical sector.
Keyphrases
  • ionic liquid
  • mental health
  • public health
  • adverse drug
  • physical activity
  • drug induced
  • climate change
  • health information
  • health promotion