Corn Silk Flavonoids Ameliorate Hyperuricemia via PI3K/AKT/NF-κB Pathway.
Xizhu WangLiu DongYifei DongZhijie BaoSongyi LinPublished in: Journal of agricultural and food chemistry (2023)
Hyperuricemia (HUA) is a widespread metabolic disease marked by an elevated level of uric acid, and is a risk factor for premature death. The protective effect of corn silk flavonoids (CSF) against HUA and its potential mechanisms were explored. Five important apoptosis and inflammation-related signaling pathways were identified by network pharmacological analysis. The CSF exhibited significant uric acid (UA)-lowering activity in vitro by decreasing xanthine oxidase (XOD) and increasing hypoxanthine-guanine phosphoribosyl transferase levels. In a potassium oxonate-induced HUA in vivo , CSF treatment effectively inhibited XOD activity and promoted UA excretion. Furthermore, it decreased the levels of TNF-α and IL-6 and restored pathological damage. In summary, CSF is a functional food component to improve HUA by reducing inflammation and apoptosis through the down-regulating PI3K/AKT/NF-κB pathway.
Keyphrases
- uric acid
- pi k akt
- cell cycle arrest
- signaling pathway
- oxidative stress
- metabolic syndrome
- cell proliferation
- diabetic rats
- induced apoptosis
- endoplasmic reticulum stress
- epithelial mesenchymal transition
- rheumatoid arthritis
- cerebrospinal fluid
- cell death
- high glucose
- drug induced
- lps induced
- risk assessment
- tissue engineering
- human health