HLA gene polymorphism is a modifier of age-related breast cancer penetrance in carriers of BRCA1 pathogenic alleles.

Ekatherina Sh Kuligina Aleksandr A Romanko Tatjana Jankevic Aleksandr S Martianov Alexandr O Ivantsov Tatyana N SokolovaDmitry TrofimovAniruddh Kashyap Cezary Cybulski Jan A Lubiński Evgeny N Imyanitov

Published in: Breast cancer research and treatment (2024)

HLA polymorphism may play a role in modifying the penetrance of BRCA1 pathogenic variants. Certain HLA alleles or HLA homozygosity may modify the risk of BC in BRCA1 carriers.

Keyphrases

breast cancer risk
copy number
gene expression
young adults