CREBZF as a Key Regulator of STAT3 Pathway in the Control of Liver Regeneration in Mice.

Zhimin HuYamei HanYuxiao LiuZehua ZhaoFengguang MaAoyuan CuiFeifei ZhangZhengshuai LiuYaqian XueJinyun BaiHaifu WuHua BianY Eugene ChinYing YuZhuoxian MengHua WangYong LiuJiangao FanXin GaoYan Chen Yu Li

Published in: Hepatology (Baltimore, Md.) (2020)

These results characterize CREBZF as a coregulator of STAT3 to inhibit regenerative capacity, which may represent an essential cellular signal to maintain liver mass homeostasis. Therapeutic approaches to inhibit CREBZF may benefit the compromised liver during liver transplantation.

Keyphrases

stem cells
cell proliferation
mesenchymal stem cells
transcription factor
high fat diet induced
metabolic syndrome
adipose tissue
insulin resistance