Is High-Frequency Activity at Seizure Onset Inhibitory? A Stereoelectroencephalographic Study of Motor Cortex Seizures.
Hussam ShakerJian LiMasako KobayashiOlesya GrinenkoJuan BulacioRichard M LeahyPatrick ChauvelPublished in: Annals of neurology (2024)
This study supports the hypothesis of an inhibitory effect of ictal HFAs. The frequency range in the gamma band was associated with the direction of the clinical output effect. Changes from inhibitory to excitatory effect occurred when discharge frequency dropped to low gamma or beta. ANN NEUROL 2024;95:1127-1137.