Determinants of intramyocellular lipid accumulation in early childhood.
Navin MichaelVarsha GuptaSuresh Anand SadananthanAparna SampathkumarLi ChenHong PanMya-Thway TintKuan Jin LeeSee Ling LoyIzzuddin M ArisLynette Pei-Chi ShekFabian Kok Peng YapKeith M GodfreyMelvin Khee-Shing LeowYung Seng LeeMichael S KramerChristiani Jeyakumar HenryMarielle Valerie FortierYap Seng ChongPeter D GluckmanNeerja KarnaniS Sendhil VelanPublished in: International journal of obesity (2005) (2019)
This study provides evidence that IMCL accumulation occurs in early childhood and that developmental factors and race are associated with it. We also show that early childhood IMCL accumulation is well tolerated, suggesting that the adverse associations between IMCL and insulin resistance may emerge at older ages.