A GWAS meta-analysis from 5 population-based cohorts implicates ion channel genes in the pathogenesis of irritable bowel syndrome.
Ferdinando BonfiglioM HenströmA NagF HadizadehT ZhengM C CenitE TigchelaarF WilliamsA ReznichenkoW E EkN V RiveraG HomuthA A AghdassiT KacprowskiM MännikköV KarhunenL BujandaJ RafterC WijmengaJ RonkainenP HysiA ZhernakovaMauro D'AmatoPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2018)
Our results confirm the feasibility of population-based studies for gene-discovery efforts in IBS, identify risk genes and loci to be prioritized in independent follow-ups, and pinpoint ion channels as important players and potential therapeutic targets warranting further investigation.
Keyphrases
- irritable bowel syndrome
- genome wide
- genome wide identification
- systematic review
- dna methylation
- case control
- copy number
- genome wide analysis
- bioinformatics analysis
- small molecule
- genome wide association study
- meta analyses
- high throughput
- transcription factor
- quality improvement
- genome wide association
- high school