Exposure to ambient air pollution and autoantibody status in rheumatoid arthritis.
Asha M AlexGary KunkelHarlan SaylesJorge D Flautero ArcosTed R MikulsGail S KerrPublished in: Clinical rheumatology (2019)
In an elderly cohort of RA patients, fine particulate matter (PM2.5) exposure independently predicted higher ACPA concentration. Further study of fine particulate matter in the pathogenesis of RA is warranted. Key Points • A study that integrates both genetic and environmental exposure data, relative to RA autoantibody status. • Of different air pollutants measures, exposure to fine particulate matter (PM2.5) appears to be most closely linked to ACPA titers.
Keyphrases
- end stage renal disease
- particulate matter
- air pollution
- peritoneal dialysis
- rheumatoid arthritis
- disease activity
- lung function
- ankylosing spondylitis
- interstitial lung disease
- systemic lupus erythematosus
- electronic health record
- copy number
- machine learning
- artificial intelligence
- idiopathic pulmonary fibrosis
- newly diagnosed
- ejection fraction
- human health
- prognostic factors
- patient reported outcomes