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PRL -1149T allele (rs1341239) is associated with decreased risk of rheumatoid arthritis in population from southern Mexico: analysis of mRNA expression and PRL serum levels.

J E Navarro-ZarzaJ F Muñoz-ValleC J Baños-HernándezI Parra-RojasZ Reyes-CastilloH Rangel-VillalobosJorge Hernández-Bello
Published in: Clinical rheumatology (2019)
• PRL -1149T allele is a marker of decreased RA susceptibility in population from southern Mexico. • PRL -1149TT genotype is associated with low PRL mRNA expression. • RA patients have higher mRNA expression and soluble levels of PRL than healthy subjects. • PRL serum levels are higher in those RA patients with < 2 years of disease evolution.
Keyphrases
  • rheumatoid arthritis
  • disease activity
  • ankylosing spondylitis
  • ejection fraction
  • newly diagnosed
  • interstitial lung disease
  • systemic lupus erythematosus
  • chronic kidney disease
  • patient reported