RNA interference in glial cells for nerve injury treatment.

Junquan LinSeung Bin JoTae-Hyun KimHae-Won Kim Sing Yian Chew

Published in: Journal of tissue engineering (2020)

Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat nerve injuries sustained in the central nervous system. In addition, the various methods of delivering these RNA interference effectors will be discussed.

Keyphrases

induced apoptosis
cell cycle arrest
nucleic acid
endoplasmic reticulum stress
oxidative stress
risk assessment
copy number
genome wide
gene expression
cell death
small molecule
neuropathic pain
drug delivery
cell proliferation
spinal cord
pi k akt
genome wide identification