Clinical Impact of Noninvasive Plasma Microbial Cell-Free Deoxyribonucleic Acid Sequencing for the Diagnosis and Management of Pneumocystis jirovecii Pneumonia: A Single-Center Retrospective Study.

Kap Sum FoongMojolaoluwa MabayojeAbeer AlMajali

Published in: Open forum infectious diseases (2022)

We present 23 cases of Pneumocystis jirovecii pneumonia (PCP) diagnosed with commercially available noninvasive plasma microbial cell-free deoxyribonucleic acid (mcfDNA) assay. Our findings suggest that plasma mcfDNA testing resulted in positive clinical impact for the diagnosis and treatment of PCP and coinfections in 82.6% of cases.

Keyphrases

cell free
microbial community
circulating tumor
high throughput
single cell
respiratory failure
community acquired pneumonia
acute respiratory distress syndrome
mechanical ventilation