Neuronal and astrocytic tetraploidy is increased in drug-resistant epilepsy.
Ancor Sanz-GarcíaPatricia Sánchez-JiménezInmaculada Granero-CremadesMaría de ToledoPaloma PulidoMarta NavasJosé María FradeMatilde Desirée Pereboom-MaicasCristina Virginia Torres-DíazMaría C Ovejero-BenitoPublished in: Neuropathology and applied neurobiology (2023)
We demonstrated the presence of both tetraploid neurons and astrocytes in healthy subjects as well as increased levels of both cell populations in DRE patients. Herein, we describe for the first time the presence of tetraploid astrocytes in healthy subjects. Furthermore, these results provide new insights into epilepsy, opening new avenues for future treatment.