Autoimmune manifestations among 461 patients with monogenic inborn errors of immunity.
Gholamreza AziziMarzieh TavakolReza YazdaniSamaneh DelavariTannaz Moeini ShadSeyed Erfan RasouliMahnaz JameeSalar PashangzadehArash KalantariMansoureh ShariatAlireza ShafieiJavad MohammadiGholamreza HassanpourZahra ChavoshzadehSeyed Alireza MahdavianiTooba MomenNasrin BehniafardMohammad NabaviMohammad Hassan BemanianSaba ArshiRasol MolatefiRoya SherkatAfshin ShirkaniSoheila AlyasinFarahzad Jabbari-AzadJavad GhaffariMehrnaz MesdaghiHamid AhanchianMaryam KhoshkhuiMohammad Hossein EslamianTaher CheraghiAbbas DabbaghzadehRasoul Nasiri KalmarziHossein EsmaeilzadehJavad TafarojiAbbas KhaliliMahnaz Sadeghi-ShabestariSepideh DarougarMojgan MoghtaderiAkefeh AhmadiafsharBehzad ShakerianMarzieh HeidarzadehBabak GhalebaghiSeyed Mohammad FathiBehzad DarabiMorteza FallahpourAzam MohsenzadehSarehsadat EbrahimiSamin SharafianAhmad VosughimotlaghMitra TafakoridelbariMaziyar Rahimi Haji-AbadiParisa AshourniaAnahita RazaghianArezou RezaeiFereshte SalamiPaniz ShirmastNasrin BazarganSetareh MamishiHossein Ali KhazaeiBabak NegahdariSima ShokriSeyed Hesamedin NabavizadehSaeed BazregariRamin GhasemiShiva BayatHamid EshaghiNima RezaeiHassan AbolhassaniAsghar AghamohammadiPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2021)
Autoimmune phenomena are common features among patients with monogenic IEI and are associated with a more complicated course of the disease. Therefore, when encountering autoimmune disorders, especially in the setting of dysgammaglobulinemia, it would be appropriate to conduct next-generation sequencing to discover responsible genes for the immune dysregulation at an early stage of the disease.