Arginine regulates HSPA5/BiP translation through ribosome pausing in triple-negative breast cancer cells.

Christina M VidalChing OuyangYue QiCarlos Mendez-DorantesAlaysia CoblentzJackelyn A Alva-OrnelasJeremy M StarkVictoria L SeewaldtDavid K Ann

Published in: British journal of cancer (2023)

In conclusion, these findings suggest that the downregulation of BiP disrupts proteostasis during arginine shortage-induced non-canonical ER stress and plays a key role in cell growth inhibition, indicating BiP as a target of codon-specific ribosome pausing upon arginine shortage.

Keyphrases

nitric oxide
breast cancer cells
amino acid
high glucose
cell proliferation
diabetic rats
signaling pathway
heat shock protein
drug induced