Characterization and functional analysis of the proteins Prohibitin 1 and 2 in Trypanosoma cruzi.
Ana Karina Ibarrola VannucciLuis M De PablosLissette Retana-MoreiraAlberto Cornet-GomezTeresa Cruz-BustosAlejandro G SchijmanJosé L RamírezSusana VílchezAntonio OsunaPublished in: PLoS neglected tropical diseases (2021)
This research expands our understanding of the functions of PHBs in the life cycle of the parasite. It also highlights the protective role of prohibitins against ROS and reveals that the absence of PHB2 has a lethal effect on the parasite, a fact that could support the consideration of this protein as a possible target for therapeutic action.