NFIL3 mutations alter immune homeostasis and sensitise for arthritis pathology.

Susan SchlennerEmanuela PasciutoVasiliki LagouOliver BurtonTeresa PrezzemoloSteffie JuniusCarlos P RocaCyril SeilletCynthia LouisJames DooleyKylie LuongErika Van NieuwenhoveIan P WicksGabrielle BelzStéphanie Humblet-BaronCarine WoutersAdrian Liston

Published in: Annals of the rheumatic diseases (2018)

NFIL3 mutation can sensitise for arthritis development, in mice and humans, and rewires the innate immune system for IL-1β over-production.

Keyphrases

rheumatoid arthritis
immune response
high fat diet induced
type diabetes
adipose tissue
skeletal muscle
insulin resistance