Overcoming High Trabectedin Resistance of Soft-tissue Sarcoma With Recombinant Methioninase: A Potential Solution of a Recalcitrant Clinical Problem.

Sei MorinagaQinghong HanKohei MizutaByung M KangMotokazu SatoMichael BouvetNorio YamamotoKatsuhiro HayashiHiroaki KimuraShinji MiwaKentaro IgarashiTakashi HiguchiHiroyuki TsuchiyaSatoru DemuraRobert M Hoffman

Published in: Anticancer research (2024)

The combined administration of trabectedin and rMETase was synergistic on the viability of TR-HT1080 cells in vitro. The combination of rMETase and trabectedin has promising clinical potential for overcoming chemo-resistance of soft-tissue sarcoma.

Keyphrases

induced apoptosis
cancer therapy
human health
signaling pathway
drug delivery
risk assessment
climate change
locally advanced
pi k akt