Cyanoacetylenes as Triggers and Partners in KOH-Assisted Assemblies of Quinoline-Based Dihydropyrimido[1,2-a]quinolin-3-ones on Water.
Kseniya V BelyaevaLina P NikitinaAnastasiya G Mal'kinaAndrei V AfoninAlexander V VashchenkoBoris A TrofimovPublished in: The Journal of organic chemistry (2019)
Arylcyanoacetylenes trigger the assembly of dihydropyrimido[1,2-a]quinolin-3-ones in good to excellent yields on the platform of quinolines in the presence of KOH in aqueous media at room temperature. This green on-water methodology provides a simple one-pot access to a novel family of the pharmaceutically prospective compounds.