Vitamin D enhances reactive oxygen intermediates production in phagocytic cells in term and preterm infants.

Chike OnwunemeAlfonso BlancoAmanda O'NeillBill WatsonEleanor J Molloy

Published in: Pediatric research (2015)

Neonatal phagocytic cells had diminished ROI production in the presence of LPS, however, pretreatment with 1,25OHD reversed this hyporesponsiveness. This action by 1,25OHD was mediated by activation of nicotinamide adenine dinucleotide phosphate oxidase system through PI3K signaling enzymes.

Keyphrases

preterm infants
induced apoptosis
cell cycle arrest
low birth weight
endoplasmic reticulum stress
oxidative stress
preterm birth