Severe tricuspid regurgitation due to interactions with right ventricular permanent pacemaker or defibrillator leads.
Cory R TrankleZachary M GertzJayanthi N KoneruVigneshwar KasirajanPatricia NicolatoHem L BhardwajKenneth A EllenbogenGautham KalahastyPublished in: Pacing and clinical electrophysiology : PACE (2018)
Although thought to be a rare event, permanent pacemakers and implantable cardioverter-defibrillators with right ventricular intracardiac leads have the potential to induce tricuspid valve dysfunction. Adverse lead-valve interactions can take place through a variety of mechanisms including damage at the time of implantation, leaflet pinning, or long-term fibrosis encapsulating the leaflet tissue. Clinical manifestations can display a wide range of severity, as well as a highly variable time span between implantation and hemodynamic deterioration. This review aims to describe the potential pathophysiologic effects of intracardiac device leads on the tricuspid valve, with a focus on ideal diagnostic strategies and treatment options once lead-induced valvular dysfunction is suspected.
Keyphrases
- aortic valve
- mitral valve
- aortic stenosis
- transcatheter aortic valve replacement
- oxidative stress
- left atrial appendage
- diabetic rats
- cardiac resynchronization therapy
- high glucose
- drug induced
- human health
- early onset
- emergency department
- pulmonary embolism
- atrial fibrillation
- coronary artery disease
- risk assessment