Clinico-pathological features in fatal COVID-19 infection: a preliminary experience of a tertiary care center in North India using postmortem minimally invasive tissue sampling.
Animesh RayDeepali JainAyush GoelShubham AgarwalShekhar SwaroopPrasenjit DasSudheer Kumar AravaAsit Ranjan MridhaAruna NambirajanGeetika SinghS ArulselviPurva MathurSanchit KumarShubham SahniJagbir Nehranull NazneenMouna BmNeha RastogiSandeep MahatoChaavi GuptaS BharadhanGaurav DhitalPawan GoelPraful PandeySantosh KnShitij ChaudharyVishakh C KeriVishal Singh ChauhanNiranjan MahishiAnand ShahiRagu RBaidnath K GuptaRicha AggarwalKapil Dev SoniNeeraj NischalManish SonejaSanjeev LalwaniChitra SarkarRandeep GuleriaNaveet WigAnjan TrikhaPublished in: Expert review of respiratory medicine (2021)
Predominant finding was diffuse alveolar damage with demonstration of SARS-CoV-2 protein in the acute phase. Microvascular thrombi were rarely identified in any organ. Substantial hepatocyte necrosis, Kupffer cell hypertrophy, microvesicular, and macrovesicular steatosis unrelated to microvascular thrombi suggested that liver might be a primary target of COVID-19.