A Genomic Risk Score Identifies Individuals at High Risk for Intracerebral Hemorrhage.
Evangelos Pavlos MyserlisMarios K GeorgakisStacie L DemelPadmini SekarJaeyoon ChungRainer MalikHyacinth I HyacinthMary E ComeauGuido J FalconeCarl D LangefeldJonathan RosandDaniel WooChristopher D AndersonPublished in: Stroke (2023)
We developed and validated a genomic risk score that predicts lifetime risk of ICH beyond established clinical risk factors among individuals of European ancestry. Whether implementation of the score in risk prognostication models for high-risk populations, such as patients under antithrombotic treatment, could improve clinical decision making should be explored in future studies.
Keyphrases
- risk factors
- end stage renal disease
- decision making
- ejection fraction
- chronic kidney disease
- newly diagnosed
- primary care
- healthcare
- copy number
- brain injury
- peritoneal dialysis
- prognostic factors
- genome wide
- atrial fibrillation
- gene expression
- patient reported outcomes
- current status
- dna methylation
- replacement therapy