A Step Toward Personalized Surgical Decision Making: Machine Learning Predicts One Versus Numerous Melanoma Lymph Node Metastases Using RNA-Sequencing.

Gene expression profiles together with clinical variables can distinguish melanoma metastasis patients with 1 pLN versus >1 pLN. Future models trained using PET/CT imaging, gene expression, and relevant clinical variables may further improve accuracy and may predict patients who can be managed with a targeted LN excision rather than a complete TLND.