First World Consensus Conference on pancreas transplantation: Part II - recommendations.
Ugo BoggiFabio VistoliAxel AndresHelmut P ArbogastLionel BadetWalter BarontiStephen T BartlettEnrico BenedettiJulien BranchereauGeorge W BurkeFanny BuronRossana CaldaraMassimo CardilloDaniel CasanovaFederica CiprianiMatthew CooperAdamasco CupistiJosè DavideCinthia B DrachenbergEelco J P de KoningGiuseppe Maria EttorreLaureano Fernandez CruzJonathan A FridellPeter J FriendLucrezia FurianOsama A GaberAngelika C GruessnerRainer W G GruessnerJenny E GuntonDuck-Jong HanSara IacopiEmanuele Federico KauffmannDixon B KaufmanTakashi KenmochiHussein A KhambaliaQuirino LaiRobert M LangerPaola MaffiLorella MarselliFrancesco MenichettiMario MiccoliShruti MittalEmmanuel MorelonNiccolò NapoliFlavia NeriJose OberholzerJon S OdoricoRobert OellingerGabriel C OniscuGiuseppe OrlandoMonica OrtenziMarcelo PerosaVittorio Grazio PerroneHenry C C PleassRobert R RedfieldClaudio RicciPaolo RigottiR Paul RobertsonLainie Friedman RossMassimo RossiFrantišek SaudekJoseph R ScaleaPeter SchenkerAntonio SecchiCarlo SocciDonzília SilvaJean Paul SquiffletPeter G StockRobert J StrattaChiara TerrenzioPablo Daniel UvaChristopher J E WatsonSteven A WhitePiero MarchettiRaja KandaswamyThierry BerneyPublished in: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2021)
The First World Consensus Conference on Pancreas Transplantation provided 49 jury deliberations regarding the impact of pancreas transplantation on the treatment of diabetic patients, and 110 experts' recommendations for the practice of pancreas transplantation. The main message from this consensus conference is that both simultaneous pancreas-kidney transplantation (SPK) and pancreas transplantation alone can improve long-term patient survival, and all types of pancreas transplantation dramatically improve the quality of life of recipients. Pancreas transplantation may also improve the course of chronic complications of diabetes, depending on their severity. Therefore, the advantages of pancreas transplantation appear to clearly surpass potential disadvantages. Pancreas after kidney transplantation increases the risk of mortality only in the early period after transplantation, but is associated with improved life expectancy thereafter. Additionally, preemptive SPK, when compared to SPK performed in patients undergoing dialysis, appears to be associated with improved outcomes. Time on dialysis has negative prognostic implications in SPK recipients. Increased long-term survival, improvement in the course of diabetic complications, and amelioration of quality of life justify preferential allocation of kidney grafts to SPK recipients. Audience discussions and live voting are available online at the following URL address: http://mediaeventi.unipi.it/category/1st-world-consensus-conference-of-pancreas-transplantation/246.