Biomarkers for Deep Brain Stimulation in Animal Models of Depression.
Jason YuenAaron E RusheenJoshua Blair PriceAbhijeet S BarathHojin ShinAbbas Z KouzaniMichael BerkCharles D BlahaKendall H LeeYoonbae OhPublished in: Neuromodulation : journal of the International Neuromodulation Society (2021)
Overall, DBS is a promising therapeutic modality for treatment-resistant depression. Different outcomes have been used to assess its efficacy in animal studies. From the review, electrophysiological and biochemical markers appear to offer the greatest potential as biomarkers for depression. However, to develop closed-loop DBS for depression, additional preclinical and clinical studies with a focus on identifying reliable, safe, and effective biomarkers are warranted.