Single-cell RNA-seq reveals interferon-induced guanylate-binding proteins are linked with sarcopenia.

Zhi Peng Ruoyu ZhangXiaolin KuangChen YuShiwei NiuYongjun DuDi LuShaobo LiZhaowei TengSheng Lu

Published in: Journal of cachexia, sarcopenia and muscle (2022)

Our single-cell-based results suggested that endothelial cells may play critical roles in sarcopenia development through interferon-GBP signalling pathways, highlighting new therapeutic directions to slow down or even reverse age-related sarcopenia.

Keyphrases

rna seq
single cell
endothelial cells
skeletal muscle
high glucose
high throughput
dendritic cells
community dwelling
diabetic rats
drug induced
oxidative stress
immune response