A Standardized Framework for Fluorescence-Guided Margin Assessment for Head and Neck Cancer Using a Tumor Acidosis Sensitive Optical Imaging Agent.
Pieter Jan SteinkampFloris Jan VoskuilBert van der VegtJan Johannes DoffKees-Pieter SchepmanSebastiaan Antonius Hendrik Johannes de VisscherWendy KelderYalia JayalakshmiJinming GaoBaran Devrim SumerGooitzen Michell van DamMax Johannes Hendrikus WitjesPublished in: Molecular imaging and biology (2021)
Our specimen-driven fluorescence framework using a novel, pH-activatable, fluorescent imaging agent could assist in reliable and real-time adequate clinical decision-making showing that a fluorescent lesion on the surgical specimen with a TBR of 1.5 is correlated to a tumor-positive resection margin. The binary mechanism of ONM-100 allows for a sharp tumor delineation in all patients, giving the surgeon a clinical tool for real-time margin assessment, with a high sensitivity.