Small intestinal bacterial overgrowth and non-alcoholic fatty liver disease diagnosed by transient elastography and liver biopsy.
Ivana MikolasevicBozena DelijaAna MijicTajana StevanovicNadija SkenderevicIvan SosaIrena Krznaric-ZrnicMaja AbramZeljko KrznaricViktor DomislovicTajana Filipec KanizajDelfa Radic-KristoAleksandar CubranicAron GrubesicRadislav NakovIvana SkrobonjaDavor StimacGoran HauserPublished in: International journal of clinical practice (2021)
In this relatively large population of patients, we used a gold standard for both SIBO (quantitative culture of duodenum's descending part aspirate) and NAFLD (LB), and we demonstrated that NASH patients and those with SF had a higher incidence of SIBO. Moreover, significant predictors independently associated with SIBO were T2DM, fibrosis stage and ballooning grade. Although TE is a well-investigated method for steatosis and fibrosis detection, in our study, independent predictors of SIBO were histological characteristics of NAFLD, while elastographic parameters did not reach statistical significance.