Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2.

Qin ZhouYi-Wei WangPeng-Fei NiYi-Nan ChenHong-Quan DongYan-Ning Qian

Published in: Journal of neuroinflammation (2018)

Based on our findings, we conclude that tryptase can trigger brain microvascular endothelial cell activation and proinflammatory mediator release. These findings may further clarify the involvement and mechanism of tryptase in BBB disruption.

Keyphrases

endothelial cells
high glucose
blood brain barrier
white matter
cerebral ischemia