Identification of candidate gene variants of monogenic diabetes using targeted panel sequencing in early onset diabetes patients.
Dong Hwa LeeSoo-Heon KwakHee Sue ParkEu Jeong KuHyun Jeong JeonTae Keun OhPublished in: BMJ open diabetes research & care (2021)
Using a targeted gene sequencing panel, we identified seven variants in either MODY genes or mitochondrial DNA using a Korean patient population with early onset diabetes who were clinically suspected of MODY. This genetic approach provides the ability to compare distinct populations of racial and ethnic groups to determine whether specific gene is involved in their diagnosis of MODY.
Keyphrases
- copy number
- early onset
- mitochondrial dna
- genome wide
- late onset
- type diabetes
- cardiovascular disease
- glycemic control
- dna methylation
- end stage renal disease
- genome wide identification
- ejection fraction
- single cell
- newly diagnosed
- cancer therapy
- chronic kidney disease
- case report
- gene expression
- adipose tissue
- pulmonary embolism
- drug delivery
- patient reported outcomes
- african american
- skeletal muscle