Pouchitis Is Associated with Paneth Cell Dysfunction and Ameliorated by Exogenous Lysosome in a Rat Model Undergoing Ileal Pouch Anal Anastomosis.

Yi XuZeqian YuJianfeng GongTenghui ZhangFeng ZhuJianfeng Gong

Published in: Microorganisms (2023)

Paneth cell dysfunction is prominent in patients and rat models of pouchitis and may be one of its causes. The decrease in Lachnospiraceae, a characteristic of dysbiosis in pouchitis, could be reserved by lysosome treatment. Lysozyme supplementation shows promise as a novel treatment strategy for pouchitis.

Keyphrases

oxidative stress
single cell
end stage renal disease
cell therapy
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
combination therapy
machine learning
mesenchymal stem cells
patient reported outcomes
single molecule