Sunitinib promotes apoptosis via p38 MAPK activation and STAT3 downregulation in oral keratinocytes.
Shohei FukadaKouji OhtaMiyuki SakumaMisaki AkagiHiroki KatoTakako NaruseTakayuki NakagawaHideo ShigeishiHiromi NishiMasaaki TakechiTomonao AikawaPublished in: Oral diseases (2022)
The present results indicate that sunitinib promotes cell injury and apoptosis in oral keratinocytes via p38 activation and STAT3 downregulation. Sunitinib-mediated oral complications may be associated with cytotoxic effects of the drug on oral keratinocytes.