Common mouse models of tauopathy reflect early but not late human disease.
Kathrin WengerArthur ViodeChristoph N SchlaffnerPatrick van ZalmLong ChengTammy DellovadeXavier LangloisAnthony BannonRui ChangTheresa R ConnorsDerek OakleyBernhard RenardJuri RappsilberBradley HymanHanno SteenJudith A SteenPublished in: Molecular neurodegeneration (2023)
AD mouse models that overexpress human Tau using risk mutations are a suitable tool for testing drug candidates that aim to intervene in the early formation of insoluble Tau species promoted by increased phosphorylation of Tau.