Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statuses.
Szu-Yuan WuYu-Ching WenChia-Chi KuYi-Chieh YangJyh-Ming ChowShun-Fa YangWei-Jiunn LeeMing-Hsien ChienPublished in: Journal of biomedical science (2019)
These findings provide a rationale for penfluridol being used as a PP2A activator for AML treatment, and the combination of penfluridol with an autophagy inhibitor may be a novel strategy for AML harboring FLT3-WT and FLT3-ITD.
Keyphrases
- acute myeloid leukemia
- cell death
- oxidative stress
- endoplasmic reticulum stress
- signaling pathway
- allogeneic hematopoietic stem cell transplantation
- cell cycle arrest
- dna damage
- clinical trial
- reactive oxygen species
- acute lymphoblastic leukemia
- inflammatory response
- cell proliferation
- immune response
- smoking cessation