Dysregulated Apoptosis and Autophagy in Childhood Epilepsy: Correlation to Clinical and Pharmacological Patterns.

Ahmed El-Abd AhmedMohammed H HassanAsmaa A AbdelfatahAli Helmi Bakri

Published in: Neuropediatrics (2024)

The study reveals that serum caspase-3 levels were significantly elevated, particularly in pharmacoresistant cases and those managed with multiple drugs. Conversely, MAP1-LC3 levels were significantly reduced in epilepsy cases, suggesting potential involvement of altered apoptosis and autophagy in childhood epilepsy.

Keyphrases

cell death
endoplasmic reticulum stress
oxidative stress
cell cycle arrest
induced apoptosis
signaling pathway
temporal lobe epilepsy
simultaneous determination
mass spectrometry
climate change
human health
high resolution
cell proliferation
gas chromatography
solid phase extraction