Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity.

Zining WangFeifei XuJie HuHongxia ZhangLei CuiWenhua LuWenzhuo HeXiaojuan WangMengyun LiHuanling ZhangWenjing XiongChunyuan XieYongxiang LiuPenghui ZhouJinyun LiuPeng HuangXiaofeng Frank QinXiaojun Xia

Published in: Journal for immunotherapy of cancer (2022)

Our findings showed that clotrimazole could trigger DC activation via the lactate-lysosome axis to promote antigen cross-presentation and could be used as a potential combination therapy approach to improving the therapeutic efficacy of anti-PD1 immunotherapy.

Keyphrases

dendritic cells
combination therapy
fluorescent probe
living cells
immune response
regulatory t cells
risk assessment