Autoantibody pathogenicity in a multifocal motor neuropathy induced pluripotent stem cell-derived model.
Oliver HarschnitzLeonard H van den BergLill Eva JohansenMarc D JansenSandra KlingRenata Vieira de SáLotte VlamWouter van RheenenHenk KarstCorette J WierengaR Jeroen PasterkampW Ludo van der PolPublished in: Annals of neurology (2016)
Our data provide evidence for the pathogenicity of anti-GM1 IgM antibodies in MMN patients and link their presence to the clinical characteristics of axonal damage and immunoglobulin responsiveness. This iPSC-derived disease model will facilitate diagnosis, studies on autoantibody pathogenicity, drug development, and screening in immune-mediated neuropathies. Ann Neurol 2016;80:71-88.